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KMID : 0960920020010020090
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Dementia and Neurocognitive Disorders
2002 Volume.1 No. 2 p.90 ~ p.94
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Comparison of the Callosal Morphometry in Subcortical Vascular Dementia and Alzheimer’s Disease
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Lee Ae-Young
Sohn Eun-Hee
Yu Seong-Dong
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Abstract
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Background: The clinical significance of callosal atrophy in demented patients has not been elucidated. We performed this study to compare the total and regional difference of corpus callosum according to dementia subtypes and analyzed the relationship with the white matter changes.
Methods: Twenty-eight patients with Alzheimer’s disease (NINDS-AIREN criteria), and 14 healthy controls were included. The total area of corpus callosum and three distinct subdivisions were measured by manual tracing with Paintshop Pro 6.02 software. The degree of white matter changes were graded by the Scheltens’ scale. The MMSE and Modified Mini-Mental State (3MS) Examination were used for cognitive function test.
Results: Total callosal area was much smaller in vascular dementia compared with those of Alzheimer’s disease and control. The degree of white matter change correlated significantly with the callosal atrophy in vascular dementia. Callosal atrophy was proportional to the cognitive decline.
Conclusion: We suggest that callosal atrophy in patients with subcortical vascular dementia may be a neuroradiological clue for the cognitive decline and reflects the cerebral white matter injury.
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KEYWORD
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Corpus callosum, Atrophy, Subcortical vascular dementia, Alzheimer’s disease
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